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KMID : 0895820050150040001
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Journal of Oriental Rehabilitation Medicine
2005 Volume.15 No. 4 p.1 ~ p.16
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Anti-pathogentic and Curative Effects of Sinseonkibo-tang (Shenxianqibu-tang: SSKBT) on the Collagen-Induced Arthritis in Rats
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Koo Bon-Kil
Shin Hye-Lan
Jin Kwang-Seon
Yoon Il-Ji
Oh Min-Seok
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Abstract
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Objectives: Cytokines play key roles in spontaneous autoimmune arthritis in CIA(collagen induced arthritis) mice, a model of rheumatoid arthritis. The object of study is to evaluate the effect of IL-6, TNF-α on development of collagen induced arthritis, on humoral and cellular immunity and on the endogenous production of IL-6, TNF-α in DBA/1J mice.
Methods: DBA/1J mice were immunized with 100㎍ bovine type II collagen in 0.1㎖ Freund’s complete adjuvant. There are three groups in this study, Which are wild type(WT), CIA-control and CIA-SSKBT(350㎎/㎏). Levels of anti-collagen antibodies, serum IL-6 and TNF-α were measured at the end of study. At week 6, CIA-control group developed arthritis while CIA-SSKBT group showed far less incidence and severity of arthritis.
Result and Conclusions: This study shows that SSKBT inhibits inflammatory effect of IL-6, TNF-α.
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KEYWORD
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Sinseonkibo-tang (Shenxianqibu-tang: SSKBT), Collagen-induced arthritis
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